Last updated: April 13, 2026

Osmotic Pressure Calculator

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Osmotic pressure

Osmotic pressure (π) is the pressure needed to stop the flow of solvent through a semipermeable membrane from a dilute to a concentrated solution. It's a colligative property used heavily in biology and medicine.

π = iMRT

Where i = van't Hoff factor, M = molarity (mol/L), R = 0.08206 L·atm/mol·K, T = temperature (K).

Biological relevance

Blood plasma has an osmotic pressure of about 7.6 atm at 37°C. IV solutions must be isotonic (same osmolarity as blood, ~0.3 M) to prevent cell lysis or crenation. Reverse osmosis uses applied pressure exceeding osmotic pressure to purify water.

mol/L
1 = molecular, 2 = NaCl, 3 = CaCl₂

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